Structural mechanisms of selectivity and gating in anion channelrhodopsins

Both designed and natural anion-conducting channelrhodopsins (dACRs and nACRs, respectively) have been widely applied in optogenetics (enabling selective inhibition of target-cell activity during animal behaviour studies), but each class exhibits performance limitations, underscoring trade-offs in c...

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Publié dans:Nature
Auteurs principaux: Kato, Hideaki E., Kim, Yoon Seok, Paggi, Joseph M., Evans, Kathryn E., Allen, William E., Richardson, Claire, Inoue, Keiichi, Ito, Shota, Ramakrishnan, Charu, Fenno, Lief E., Yamashita, Keitaro, Hilger, Daniel, Lee, Soo Yeun, Berndt, Andre, Shen, Kang, Kandori, Hideki, Dror, Ron O., Kobilka, Brian K., Deisseroth, Karl
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317992/
https://ncbi.nlm.nih.gov/pubmed/30158697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0504-5
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