Structural basis for ion selectivity in potassium-selective channelrhodopsins

KCR channelrhodopsins (K(+)-selective light-gated ion channels) have received attention as potential inhibitory optogenetic tools but more broadly pose a fundamental mystery regarding how their K(+) selectivity is achieved. Here, we present 2.5–2.7 Å cryo-electron microscopy structures of HcKCR1 and...

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Pubblicato in:Cell
Autori principali: Tajima, Seiya, Kim, Yoon Seok, Fukuda, Masahiro, Jo, YoungJu, Wang, Peter Y., Paggi, Joseph M., Inoue, Masatoshi, Byrne, Eamon F.X., Kishi, Koichiro E., Nakamura, Seiwa, Ramakrishnan, Charu, Takaramoto, Shunki, Nagata, Takashi, Konno, Masae, Sugiura, Masahiro, Katayama, Kota, Matsui, Toshiki E., Yamashita, Keitaro, Kim, Suhyang, Ikeda, Hisako, Kim, Jaeah, Kandori, Hideki, Dror, Ron O., Inoue, Keiichi, Deisseroth, Karl, Kato, Hideaki E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2023
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615185/
https://ncbi.nlm.nih.gov/pubmed/37652010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2023.08.009
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