Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma

Multiple myeloma (MM) is an incurable hematological malignancy caused by accumulation of abnormal clonal plasma cells. Despite the recent development of novel therapies, relapse of MM eventually occurs as a result of a remaining population of drug‐resistant myeloma stem cells. Side population (SP) c...

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Pubblicato in:Cancer Sci
Autori principali: Nakagawa, Makoto, Fujita, Shuhei, Katsumoto, Takuo, Yamagata, Kazutsune, Ogawara, Yoko, Hattori, Ayuna, Kagiyama, Yuki, Honma, Daisuke, Araki, Kazushi, Inoue, Tatsuya, Kato, Ayako, Inaki, Koichiro, Wada, Chisa, Ono, Yoshimasa, Yamamoto, Masahide, Miura, Osamu, Nakashima, Yasuharu, Kitabayashi, Issay
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317945/
https://ncbi.nlm.nih.gov/pubmed/30343511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13840
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