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Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells

Acute myeloid leukemia is a clonal malignant disorder derived from a small number of leukemic stem cells (LSCs). Rearrangements of the mixed lineage leukemia (MLL) gene are found in acute myeloid leukemia associated with poor prognosis. The upregulation of Hox genes is critical for LSC induction and...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Sci
Hauptverfasser: Aikawa, Yukiko, Yamagata, Kazutsune, Katsumoto, Takuo, Shima, Yutaka, Shino, Mika, Stanley, E Richard, Cleary, Michael L, Akashi, Koichi, Tenen, Daniel G, Kitabayashi, Issay
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373983/
https://ncbi.nlm.nih.gov/pubmed/25529853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12593
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