Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells

Acute myeloid leukemia is a clonal malignant disorder derived from a small number of leukemic stem cells (LSCs). Rearrangements of the mixed lineage leukemia (MLL) gene are found in acute myeloid leukemia associated with poor prognosis. The upregulation of Hox genes is critical for LSC induction and...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Aikawa, Yukiko, Yamagata, Kazutsune, Katsumoto, Takuo, Shima, Yutaka, Shino, Mika, Stanley, E Richard, Cleary, Michael L, Akashi, Koichi, Tenen, Daniel G, Kitabayashi, Issay
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373983/
https://ncbi.nlm.nih.gov/pubmed/25529853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12593
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