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Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells
Acute myeloid leukemia is a clonal malignant disorder derived from a small number of leukemic stem cells (LSCs). Rearrangements of the mixed lineage leukemia (MLL) gene are found in acute myeloid leukemia associated with poor prognosis. The upregulation of Hox genes is critical for LSC induction and...
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Veröffentlicht in: | Cancer Sci |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
BlackWell Publishing Ltd
2015
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4373983/ https://ncbi.nlm.nih.gov/pubmed/25529853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12593 |
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