Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells

Acute myeloid leukemia is a clonal malignant disorder derived from a small number of leukemic stem cells (LSCs). Rearrangements of the mixed lineage leukemia (MLL) gene are found in acute myeloid leukemia associated with poor prognosis. The upregulation of Hox genes is critical for LSC induction and...

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Dettagli Bibliografici
Pubblicato in:Cancer Sci
Autori principali: Aikawa, Yukiko, Yamagata, Kazutsune, Katsumoto, Takuo, Shima, Yutaka, Shino, Mika, Stanley, E Richard, Cleary, Michael L, Akashi, Koichi, Tenen, Daniel G, Kitabayashi, Issay
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373983/
https://ncbi.nlm.nih.gov/pubmed/25529853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12593
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