Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

Crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) have revealed overlapping binding modes for synthetic and natural/endogenous ligands, indicating competition for the orthosteric pocket. Here we show that cobinding of a synthetic ligand to the orthosteric pocket can push...

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Veröffentlicht in:eLife
Hauptverfasser: Shang, Jinsai, Brust, Richard, Mosure, Sarah A, Bass, Jared, Munoz-Tello, Paola, Lin, Hua, Hughes, Travis S, Tang, Miru, Ge, Qingfeng, Kamenekca, Theodore M, Kojetin, Douglas J
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317912/
https://ncbi.nlm.nih.gov/pubmed/30575522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43320
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