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Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ
Crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) have revealed overlapping binding modes for synthetic and natural/endogenous ligands, indicating competition for the orthosteric pocket. Here we show that cobinding of a synthetic ligand to the orthosteric pocket can push...
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| Опубликовано в: : | eLife |
|---|---|
| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317912/ https://ncbi.nlm.nih.gov/pubmed/30575522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43320 |
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