Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, mechanisms linking blood-brain barrier (BBB) disruption with neurodege...

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Publicado no:Nat Immunol
Main Authors: Ryu, Jae Kyu, Rafalski, Victoria A., Meyer-Franke, Anke, Adams, Ryan A., Poda, Suresh B., Coronado, Pamela E. Rios, Pedersen, Lars Østergaard, Menon, Veena, Baeten, Kim M., Sikorski, Shoana L., Bedard, Catherine, Hanspers, Kristina, Bardehle, Sophia, Mendiola, Andrew S., Davalos, Dimitrios, Machado, Michael R., Chan, Justin P., Plastira, Ioanna, Petersen, Mark A., Pfaff, Samuel J., Ang, Kenny K., Hallenbeck, Kenneth K., Syme, Catriona, Hakozaki, Hiroyuki, Ellisman, Mark H., Swanson, Raymond A., Zamvil, Scott S., Arkin, Michelle R., Zorn, Stevin H., Pico, Alexander R., Mucke, Lennart, Freedman, Stephen B., Stavenhagen, Jeffrey B., Nelson, Robert B., Akassoglou, Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317891/
https://ncbi.nlm.nih.gov/pubmed/30323343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0232-x
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