Endogenous Notch Signaling in Adult Kidneys Maintains Segment-Specific Epithelial Cell Types of the Distal Tubules and Collecting Ducts to Ensure Water Homeostasis

BACKGROUND: Notch signaling is required during kidney development for nephron formation and principal cell fate selection within the collecting ducts. Whether Notch signaling is required in the adult kidney to maintain epithelial diversity, or whether its loss can trigger principal cell transdiffere...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Mukherjee, Malini, deRiso, Jennifer, Otterpohl, Karla, Ratnayake, Ishara, Kota, Divya, Ahrenkiel, Phil, Chandrasekar, Indra, Surendran, Kameswaran
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2019
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317606/
https://ncbi.nlm.nih.gov/pubmed/30514723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018040440
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