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Endogenous Notch Signaling in Adult Kidneys Maintains Segment-Specific Epithelial Cell Types of the Distal Tubules and Collecting Ducts to Ensure Water Homeostasis

BACKGROUND: Notch signaling is required during kidney development for nephron formation and principal cell fate selection within the collecting ducts. Whether Notch signaling is required in the adult kidney to maintain epithelial diversity, or whether its loss can trigger principal cell transdiffere...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Mukherjee, Malini, deRiso, Jennifer, Otterpohl, Karla, Ratnayake, Ishara, Kota, Divya, Ahrenkiel, Phil, Chandrasekar, Indra, Surendran, Kameswaran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317606/
https://ncbi.nlm.nih.gov/pubmed/30514723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018040440
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