SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

BACKGROUND: The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and m...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Cell Int
Auteurs principaux: Du, Shi-chun, Zhu, Lan, Wang, Yu-xing, Liu, Jie, Zhang, Die, Chen, Yu-lu, Peng, Qing, Liu, Wei, Liu, Bin
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Primary Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317191/
https://ncbi.nlm.nih.gov/pubmed/30622440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0722-9
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