Radiosynthesis and Preliminary Biological Evaluation of (18)F-Fluoropropionyl-Chlorotoxin as a Potential PET Tracer for Glioma Imaging

PURPOSES: Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma. In this work, radiosynthesis of [(18)F]-fluoropropionyl-chlorotoxin ([(18)F]-FP-chlorotoxin) as a novel PET tracer was investigated, and biodistribution in vivo and PET imaging w...

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Detalhes bibliográficos
Publicado no:Contrast Media Mol Imaging
Main Authors: Zhao, Jing, Wang, Yu-liang, Li, Xin-bei, Gao, Si-yuan, Liu, Shao-yu, Song, Yu-kun, Wang, Jing-yan, Xiong, Ying, Ma, Hui, Jiang, Li, Yang, Zhi-yun, Tang, Gang-hua, Chu, Jian-ping
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317094/
https://ncbi.nlm.nih.gov/pubmed/30670934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8439162
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