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Radiosynthesis and Evaluation of [(11)C]EMPA as a potential PET Tracer for Orexin 2 Receptors

EMPA is a selective antagonist of orexin 2 (OX(2)) receptors. Previous literature with [(3)H]-EMPA suggest that it may be used as an imaging agent for OX(2) receptors; however, brain penetration is known to be modest. To evaluate the potential of EMPA as a PET radiotracer in non-human primate (as a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Changning, Moseley, Christian K., Carlin, Stephen M., Wilson, Colin M., Neelamegam, Ramesh, Hooker, Jacob M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664928/
https://ncbi.nlm.nih.gov/pubmed/23601709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.079
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