A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity

Dysregulated signaling via the epidermal growth factor receptor (EGFR)-family is believed to contribute to the progression of a diverse array of cancers. The most common variant of EGFR is EGFRvIII, which results from a consistent and tumor-specific in-frame deletion of exons 2–7 of the EGFR gene. T...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zebertavage, Lauren, Bambina, Shelly, Shugart, Jessica, Alice, Alejandro, Zens, Kyra D., Lauer, Peter, Hanson, Bill, Gough, Michael J., Crittenden, Marka R., Bahjat, Keith S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314576/
https://ncbi.nlm.nih.gov/pubmed/30601871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209153
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