Amplifying IFNγ signaling in DC by CD11c-specific loss of SOCS1 increases innate immunity to infection while decreasing adaptive immunity

While prophylactic vaccines provide protective humoral immunity against infectious agents, vaccines that elicit potent CD8 T cell responses are valuable tools to shape and drive cellular immunity against cancer and intracellular infection. In particular, IFNγ-polarized cytotoxic CD8 T cell immunity...

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Vydáno v:J Immunol
Hlavní autoři: Alice, Alejandro F., Kramer, Gwen, Bambina, Shelly, Baird, Jason R., Bahjat, Keith S., Gough, Michael J., Crittenden, Marka R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736417/
https://ncbi.nlm.nih.gov/pubmed/29150567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700909
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