Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

Inborn errors of human IFN-γ immunity underlie mycobacterial disease. We report a patient with mycobacterial disease due to inherited deficiency of the transcription factor T-bet. The patient has extremely low counts of circulating Mycobacterium-reactive NK, invariant NKT (iNKT), mucosal-associated...

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Publicado no:Cell
Main Authors: Yang, Rui, Mele, Federico, Worley, Lisa, Langlais, David, Rosain, Jérémie, Benhsaien, Ibithal, Elarabi, Houda, Croft, Carys A., Doisne, Jean-Marc, Zhang, Peng, Weisshaar, Marc, Jarrossay, David, Latorre, Daniela, Shen, Yichao, Han, Jing, Ogishi, Masato, Gruber, Conor, Markle, Janet, Ali, Fatima Al, Rahman, Mahbuba, Khan, Taushif, Seeleuthner, Yoann, Kerner, Gaspard, Husquin, Lucas T., Maclsaac, Julia L., Jeljeli, Mohamed, Errami, Abderrahmane, Ailal, Fatima, Kobor, Michael S., Oleaga-Quintas, Carmen, Roynard, Manon, Bourgey, Mathieu, Baghdadi, Jamila El, Boisson-Dupuis, Stéphanie, Puel, Anne, Batteux, Fréderic, Rozenberg, Flore, Marr, Nico, Pan-Hammarström, Qiang, Bogunovic, Dusan, Quintana-Murci, Lluis, Carroll, Thomas, Ma, Cindy S, Abel, Laurent, Bousfiha, Aziz, Santo, James P. Di, Glimcher, Laurie H, Gros, Philippe, Tangye, Stuart G, Sallusto, Federica, Bustamante, Jacinta, Casanova, Jean-Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770098/
https://ncbi.nlm.nih.gov/pubmed/33296702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.10.046
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