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Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity

Radiation therapy is a source of tumor antigen release that has the potential to serve as an endogenous tumor vaccination event. In preclinical models radiation therapy synergizes with checkpoint inhibitors to cure tumors via CD8 T cell responses. To evaluate the immune response initiated by radiati...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Crittenden, Marka R., Zebertavage, Lauren, Kramer, Gwen, Bambina, Shelly, Friedman, David, Troesch, Victoria, Blair, Tiffany, Baird, Jason R., Alice, Alejandro, Gough, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934473/
https://ncbi.nlm.nih.gov/pubmed/29725089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25482-w
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