Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome characterized by a preserved ejection fraction but increased diastolic stiffness and abnormalities of filling. Although the prevalence of HFpEF is high and continues to rise, no effective therapies exist; however, the diabe...

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Bibliografiska uppgifter
I publikationen:J Gen Physiol
Huvudupphovsmän: Slater, Rebecca E., Strom, Joshua G., Methawasin, Mei, Liss, Martin, Gotthardt, Michael, Sweitzer, Nancy, Granzier, Henk L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314384/
https://ncbi.nlm.nih.gov/pubmed/30567709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812259
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