Inotropic interventions do not change the resting state of myosin motors during cardiac diastole

When striated (skeletal and cardiac) muscle is in its relaxed state, myosin motors are packed in helical tracks on the surface of the thick filament, folded toward the center of the sarcomere, and unable to bind actin or hydrolyze ATP (OFF state). This raises the question of whatthe mechanism is tha...

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Publicat a:J Gen Physiol
Autors principals: Caremani, Marco, Pinzauti, Francesca, Powers, Joseph D., Governali, Serena, Narayanan, Theyencheri, Stienen, Ger J.M., Reconditi, Massimo, Linari, Marco, Lombardi, Vincenzo, Piazzesi, Gabriella
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314382/
https://ncbi.nlm.nih.gov/pubmed/30510036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812196
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