Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation

Urate is often viewed as an antioxidant. Here, we present an alternative perspective by showing that, when oxidized, urate propagates oxidative stress. Oxidation converts urate to the urate radical and the electrophilic products dehydrourate, 5-hydroxyisourate, and urate hydroperoxide, which eventua...

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發表在:J Biol Chem
Main Authors: Turner, Rufus, Brennan, Stephen O., Ashby, Louisa V., Dickerhof, Nina, Hamzah, Melanie R., Pearson, John F., Stamp, Lisa K., Kettle, Anthony J.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2018
主題:
Metabolism
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314113/
https://ncbi.nlm.nih.gov/pubmed/30385504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005237
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