Urate as a Physiological Substrate for Myeloperoxidase: IMPLICATIONS FOR HYPERURICEMIA AND INFLAMMATION

Urate and myeloperoxidase (MPO) are associated with adverse outcomes in cardiovascular disease. In this study, we assessed whether urate is a likely physiological substrate for MPO and if the products of their interaction have the potential to exacerbate inflammation. Urate was readily oxidized by M...

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Detalhes bibliográficos
Main Authors: Meotti, Flavia C., Jameson, Guy N. L., Turner, Rufus, Harwood, D. Tim, Stockwell, Samantha, Rees, Martin D., Thomas, Shane R., Kettle, Anthony J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075637/
https://ncbi.nlm.nih.gov/pubmed/21266577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172460
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