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Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation
Urate is often viewed as an antioxidant. Here, we present an alternative perspective by showing that, when oxidized, urate propagates oxidative stress. Oxidation converts urate to the urate radical and the electrophilic products dehydrourate, 5-hydroxyisourate, and urate hydroperoxide, which eventua...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314113/ https://ncbi.nlm.nih.gov/pubmed/30385504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005237 |
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