Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.

Urate oxidase, or uricase (EC 1.7.3.3), is a purine metabolic enzyme that catalyzes the conversion of uric acid to allantoin in most mammals except humans and certain other primates. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturb...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wu, X, Wakamiya, M, Vaishnav, S, Geske, R, Montgomery, C, Jones, P, Bradley, A, Caskey, C T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43025/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290593/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.742
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