Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.
Urate oxidase, or uricase (EC 1.7.3.3), is a purine metabolic enzyme that catalyzes the conversion of uric acid to allantoin in most mammals except humans and certain other primates. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturb...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1994
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43025/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290593/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.742 |
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