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Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress
BSIH ((E)-N’-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylidene)isonicotinohydrazide) is a prodrug version of the metal chelator SIH ((E)-N’-(2-hydroxybenzylidene)isonicotinohydrazide) in which a boronate group prevents metal chelation until reaction with hydrogen peroxide releases SIH, whi...
Gorde:
| Argitaratua izan da: | Bioorg Med Chem |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314015/ https://ncbi.nlm.nih.gov/pubmed/30429096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.11.004 |
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