Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products

Free cellular iron catalyzes the formation of toxic hydroxyl radicals and therefore chelation of iron could be a promising therapeutic approach in pathological states associated with oxidative stress. Salicylaldehyde isonicotinoyl hydrazone (SIH) is a strong intracellular iron chelator with well doc...

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Detalhes bibliográficos
Publicado no:Toxicology
Main Authors: Jansová, Hana, Bureš, Jan, Macháček, Miloslav, Hašková, Pavlína, Jirkovská, Anna, Roh, Jaroslav, Wang, Qin, Franz, Katherine J., Kovaříková, Petra, Šimůnek, Tomáš
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889448/
https://ncbi.nlm.nih.gov/pubmed/27046792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.03.004
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