Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

Catecholamines may undergo iron-promoted oxidation resulting in formation of reactive intermediates (aminochromes) capable of redox cycling and reactive oxygen species (ROS) formation. Both of them induce oxidative stress resulting in cellular damage and death. Iron chelation has been recently shown...

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Veröffentlicht in:Toxicology
Hauptverfasser: Hašková, Pavlína, Jansová, Hana, Bureš, Jan, Macháček, Miloslav, Jirkovská, Anna, Franz, Katherine J., Kovaříková, Petra, Šimůnek, Tomáš
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134745/
https://ncbi.nlm.nih.gov/pubmed/27744045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.10.004
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