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Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress
BSIH ((E)-N’-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylidene)isonicotinohydrazide) is a prodrug version of the metal chelator SIH ((E)-N’-(2-hydroxybenzylidene)isonicotinohydrazide) in which a boronate group prevents metal chelation until reaction with hydrogen peroxide releases SIH, whi...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314015/ https://ncbi.nlm.nih.gov/pubmed/30429096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.11.004 |
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