VP4- and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans

Human rotaviruses (RVs) are the leading cause of severe diarrhea in young children worldwide. The molecular mechanisms underlying the rapid induction of heterotypic protective immunity to RV, which provides the basis for the efficacy of licensed monovalent RV vaccines, have remained unknown for more...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Nair, Nitya, Feng, Ningguo, Blum, Lisa K., Sanyal, Mrinmoy, Ding, Siyuan, Jiang, Baoming, Sen, Adrish, Morton, John M., He, Xiao-Song, Robinson, William H., Greenberg, Harry B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312383/
https://ncbi.nlm.nih.gov/pubmed/28637924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam5434
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