Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of VP7 and the VP8 fragment of VP4.

A murine model was used to determine whether neutralizing monoclonal antibodies (MAbs) with heterotypic specificity directed to VP7 (MAb 57-8) or to the VP8 fragment of VP4 (MAb M14) passively protect mice against challenge with various strains of rotavirus. (The gene 4 product, an outer capsid prot...

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Bibliographic Details
Main Authors: Matsui, S M, Offit, P A, Vo, P T, Mackow, E R, Benfield, D A, Shaw, R D, Padilla-Noriega, L, Greenberg, H B
Format: Artigo
Language:Inglês
Published: 1989
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC267419/
https://ncbi.nlm.nih.gov/pubmed/2470774
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