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Formation of Complex α-Imino Esters via Multihetero-Cope Rearrangement of α-Keto Ester Derived Nitrones

A sequential benzoylation and multihetero-Cope rearrangement of α-keto ester derived nitrones has been developed. The reaction furnishes a diverse array of complex α-imino ester derivatives. The products can be transformed into amino alcohols via LiAlH(4) reduction.

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Detalhes bibliográficos
Publicado no:Synthesis (Stuttg)
Main Authors: Bartlett, Samuel L., Keiter, Kimberly M., Zavesky, Blane P., Johnson, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311990/
https://ncbi.nlm.nih.gov/pubmed/30607036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0037-1610391
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