Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis

The linear ubiquitin chain assembly complex (LUBAC) regulates NF-κB activation by modifying proteins with linear (M1-linked) ubiquitination chains. Although LUBAC also regulates the apoptosis pathway, the precise mechanism by which LUBAC regulates apoptosis remains not fully defined. Here, we report...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Tang, Yong, Joo, Donghyun, Liu, Guangna, Tu, Hailin, You, Jeffrey, Jin, Jianping, Zhao, Xueqiang, Hung, Mien-Chie, Lin, Xin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2018
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311529/
https://ncbi.nlm.nih.gov/pubmed/30361438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005449
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