The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA

Mitochondrial inner membrane protein MPV17 is a protein of unknown function that is associated with mitochondrial DNA (mtDNA)-depletion syndrome (MDS). MPV17 loss-of-function has been reported to result in tissue-specific nucleotide pool imbalances, which can occur in states of perturbed folate-medi...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Alonzo, Judith R., Venkataraman, Chantel, Field, Martha S., Stover, Patrick J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311524/
https://ncbi.nlm.nih.gov/pubmed/30385507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004788
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