p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid–Nonresponsive Neural Tube Defects in Mice

BACKGROUND: Neural tube defects (NTDs) occur in nervous tissue during embryogenesis when the neural tube fails to close. Approximately 70% of all human NTDs can be prevented by folic acid (FA). Altered expression and/or function of the tumor suppressor protein p53 can lead to NTDs in mouse models. O...

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Udgivet i:J Nutr
Main Authors: Lachenauer, Erica R, Stabler, Sally P, Field, Martha S, Stover, Patrick J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Biochemical, Molecular, and Genetic Mechanisms
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690762/
https://ncbi.nlm.nih.gov/pubmed/32271909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jn/nxaa090
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