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Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice(1)(2)(3)
Background: MTHFD1 encodes C1-tetrahydrofolate synthase, which is a folate-dependent enzyme that catalyzes the formation and interconversion of folate-activated one-carbon groups for nucleotide biosynthesis and cellular methylation. A polymorphism in MTHFD1 (1958G→A) impairs enzymatic activity and i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Nutrition
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3302363/ https://ncbi.nlm.nih.gov/pubmed/22378735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.111.030783 |
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