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Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice(1)(2)(3)(4)
Background: Folic acid supplementation prevents the occurrence and recurrence of neural tube defects (NTDs), but the causal metabolic pathways underlying folic acid–responsive NTDs have not been established. Serine hydroxymethyltransferase (SHMT1) partitions folate-derived one-carbon units to thymid...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Nutrition
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057548/ https://ncbi.nlm.nih.gov/pubmed/21346092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.110.002766 |
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