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Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice(1)(2)(3)(4)

Background: Folic acid supplementation prevents the occurrence and recurrence of neural tube defects (NTDs), but the causal metabolic pathways underlying folic acid–responsive NTDs have not been established. Serine hydroxymethyltransferase (SHMT1) partitions folate-derived one-carbon units to thymid...

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Autors principals: Beaudin, Anna E, Abarinov, Elena V, Noden, Drew M, Perry, Cheryll A, Chu, Stephanie, Stabler, Sally P, Allen, Robert H, Stover, Patrick J
Format: Artigo
Idioma:Inglês
Publicat: American Society for Nutrition 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057548/
https://ncbi.nlm.nih.gov/pubmed/21346092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.110.002766
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