The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice

The pleiotropic interleukin-6 (IL-6)–type cytokine oncostatin M (OSM) signals in multiple cell types, affecting processes such as cell differentiation, hematopoiesis, and inflammation. In humans, OSM exerts its effects through activation of either of two different heterodimeric receptor complexes, f...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Adrian-Segarra, Juan M., Sreenivasan, Krishnamoorthy, Gajawada, Praveen, Lörchner, Holger, Braun, Thomas, Pöling, Jochen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311520/
https://ncbi.nlm.nih.gov/pubmed/30373773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004375
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