The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice

The pleiotropic interleukin-6 (IL-6)–type cytokine oncostatin M (OSM) signals in multiple cell types, affecting processes such as cell differentiation, hematopoiesis, and inflammation. In humans, OSM exerts its effects through activation of either of two different heterodimeric receptor complexes, f...

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Publicado en:J Biol Chem
Autores principales: Adrian-Segarra, Juan M., Sreenivasan, Krishnamoorthy, Gajawada, Praveen, Lörchner, Holger, Braun, Thomas, Pöling, Jochen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311520/
https://ncbi.nlm.nih.gov/pubmed/30373773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004375
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