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The AB loop and D-helix in binding site III of human Oncostatin M (OSM) are required for OSM receptor activation
Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are closely related members of the interleukin-6 (IL-6) cytokine family. Both cytokines share a common origin and structure, and both interact through a specific region, termed binding site III, to activate a dimeric receptor complex formed by...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5936835/ https://ncbi.nlm.nih.gov/pubmed/29511087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001920 |
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