A Unique Loop Structure in Oncostatin M Determines Binding Affinity toward Oncostatin M Receptor and Leukemia Inhibitory Factor Receptor

Oncostatin M (OSM) and leukemia inhibitory factor are pleiotropic cytokines that belong to the interleukin-6 (IL-6) family. These cytokines play a crucial role in diverse biological events like inflammation, neuroprotection, hematopoiesis, metabolism, and development. The family is grouped together...

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Hauptverfasser: Chollangi, Srinivas, Mather, Timothy, Rodgers, Karla K., Ash, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463309/
https://ncbi.nlm.nih.gov/pubmed/22829597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.387324
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