A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug‐Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide

Evofosfamide is a cytotoxic small‐molecule prodrug preferentially activated under hypoxic conditions. The cytotoxicity of evofosfamide impacted the generation of in vitro drug‐drug interaction (DDI) data, especially in vitro induction results. Therefore, a novel physiologically based pharmacokinetic...

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Bibliografski detalji
Izdano u:CPT Pharmacometrics Syst Pharmacol
Glavni autori: Lüpfert, Christian, Dyroff, Martin, von Richter, Oliver, Gallemann, Dieter, El Bawab, Samer, Dolgos, Hugues, Jung, Don, Hecht, Stefan, Johne, Andreas
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310869/
https://ncbi.nlm.nih.gov/pubmed/30311747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12360
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