The Effect of 5-Aminolevulinic Acid on Cytochrome P450-Mediated Prodrug Activation

Of late, numerous prodrugs are widely used for therapy. The hemeprotein cytochrome P450 (CYP) catalyzes the activation of prodrugs to form active metabolites. Therefore, the activation of CYP function might allow the use of lower doses of prodrugs and decrease toxicity. We hypothesized that the addi...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Miura, Mai, Ito, Kensuke, Hayashi, Maiko, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504516/
https://ncbi.nlm.nih.gov/pubmed/26181717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131793
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