Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association with the HLA DQB1*06:02/DQA1*01:02 (98% vs. 25%) heterodimer (DQ0602), T cell receptors (TCR) and other immune loci suggest autoimmunity but autoantigens are unknown. Onset is seasonal and associated with influe...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Luo, Guo, Ambati, Aditya, Lin, Ling, Bonvalet, Mélodie, Partinen, Markku, Ji, Xuhuai, Maecker, Holden Terry, Mignot, Emmanuel Jean-Marie
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310865/
https://ncbi.nlm.nih.gov/pubmed/30541895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818150116
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires