Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association with the HLA DQB1*06:02/DQA1*01:02 (98% vs. 25%) heterodimer (DQ0602), T cell receptors (TCR) and other immune loci suggest autoimmunity but autoantigens are unknown. Onset is seasonal and associated with influe...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Luo, Guo, Ambati, Aditya, Lin, Ling, Bonvalet, Mélodie, Partinen, Markku, Ji, Xuhuai, Maecker, Holden Terry, Mignot, Emmanuel Jean-Marie
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310865/
https://ncbi.nlm.nih.gov/pubmed/30541895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818150116
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