Modulation of HIF-2α PAS-B domain contributes to physiological responses

Hypoxia-inducible factors (HIFs) are transcription factors in the basic helix–loop–helix PER-ARNT-SIM (bHLH-PAS) protein family that contain internal hydrophobic cavities within their PAS-A and PAS-B domains. Among HIFs, the HIF-2α PAS-B domain contains a relatively large cavity exploited for the de...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Feng, Zhihui, Zou, Xuan, Chen, Yaomin, Wang, Hanzhi, Duan, Yingli, Bruick, Richard K.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310796/
https://ncbi.nlm.nih.gov/pubmed/30523118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810897115
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