SLAMF1 engagement inhibits T cell-B cell interaction and diminishes IL-6 production and plasmablast differentiation in systemic lupus erythematosus

OBJECTIVE: SLAMF1 homophilic interactions promote immunoglobulin production and T cell-B cell (T-B) cross-talk. SLAMF1 is overexpressed on T and B cells in patients with SLE. We conducted studies to determine the role of SLAMF1 monoclonal antibody in modulating T-B cell interaction and B cell activa...

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Publicado en:Arthritis Rheumatol
Autores principales: Karampetsou, Maria P., Comte, Denis, Suárez-Fueyo, Abel, Katsuyama, Eri, Yoshida, Nobuya, Kono, Michihito, Kyttaris, Vasileios C., Tsokos, George C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310084/
https://ncbi.nlm.nih.gov/pubmed/30058241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40682
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