The selective loss of SLAMF4(+) CD8(+) T cells contributes to the decreased cytotoxic cell activity in systemic lupus erythematosus

OBJECTIVE: Engagement of signaling lymphocytic activation molecule family member 4 (SLAMF4, CD244, 2B4) by its ligand SLAMF2 (CD48) modulates function and expansion of both NK cells and a subset of cytotoxic CD8(+) T cells. As the cytotoxicity of CD8(+) T lymphocytes isolated from systemic lupus ery...

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Veröffentlicht in:Arthritis Rheumatol
Hauptverfasser: Kis-Toth, Katalin, Comte, Denis, Karampetsou, Maria P., Kyttaris, Vasileios C., Kannan, Lakshmi, Terhorst, Cox, Tsokos, George C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690788/
https://ncbi.nlm.nih.gov/pubmed/26314831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39410
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