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The selective loss of SLAMF4(+) CD8(+) T cells contributes to the decreased cytotoxic cell activity in systemic lupus erythematosus
OBJECTIVE: Engagement of signaling lymphocytic activation molecule family member 4 (SLAMF4, CD244, 2B4) by its ligand SLAMF2 (CD48) modulates function and expansion of both NK cells and a subset of cytotoxic CD8(+) T cells. As the cytotoxicity of CD8(+) T lymphocytes isolated from systemic lupus ery...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4690788/ https://ncbi.nlm.nih.gov/pubmed/26314831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39410 |
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