Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress

We have shown that hydrogen peroxide (H(2)O(2)) downregulates tetrahydrobiopterin (H(4)B) salvage enzyme dihydrofolate reductase (DHFR) to result in eNOS uncoupling and elevated blood pressure. Here we aimed to delineate molecular mechanisms underlying H(2)O(2) downregulation of endothelial DHFR by...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hypertension
Hlavní autoři: Li, Hong, Li, Qiang, Zhang, Yixuan, Liu, Wenting, Gu, Bo, Narumi, Taro, Siu, Kin Lung, Youn, Ji Youn, Liu, Peiqing, Yang, Xia, Cai, Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310047/
https://ncbi.nlm.nih.gov/pubmed/30571557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11643
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky