Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress

We have shown that hydrogen peroxide (H(2)O(2)) downregulates tetrahydrobiopterin (H(4)B) salvage enzyme dihydrofolate reductase (DHFR) to result in eNOS uncoupling and elevated blood pressure. Here we aimed to delineate molecular mechanisms underlying H(2)O(2) downregulation of endothelial DHFR by...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Li, Hong, Li, Qiang, Zhang, Yixuan, Liu, Wenting, Gu, Bo, Narumi, Taro, Siu, Kin Lung, Youn, Ji Youn, Liu, Peiqing, Yang, Xia, Cai, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310047/
https://ncbi.nlm.nih.gov/pubmed/30571557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11643
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